Folinic Acid in Megaloblastic Anaemia of Pregnancy

Megaloblastic anaemia of pregnancy and the puerperium.

Megaloblastic anemia probably caused by defective utilization of folinic acid.

By FARm 1. FIAuRANI, GEORGE WANG AND L. M. T0cANrINs I HE COMMON types of megaloblastic anemias usually res1)ond well to vitamin B-12 or folic acid but there are some which respond incompletely or not at all to these antianemic agents. In 1936, Israel and \Vilkinson referred to these megaloblastic anemias which are refractory to liver extract as “Achrestic n1 ‘ Since then a number of cases have...

Extensive myeloid response during folic acid therapy in megaloblastic anaemia of pregnancy.

The patient, aged 29 years, para 3, unmarried, and of subnormal intelligence, was first seen in the thirtyfourth week of pregnancy at the hospital antenatal clinic. Previous pregnancies were uneventful and there was no record of serious illnesses. The family history was irrelevant. The present pregnancy progressed uneventfully until early in the sixth month when she had a severe haemorrhage fro...

Pigmentation in megaloblastic anaemia associated with pregnancy and lactation.

Generalized skin pigmentation in five African women with megaloblastic anaemia in the postnatal period was associated with low serum folate levels, as distinct from vitamin B(12) deficiency. It is suggested that the occurrence of pigmentation in both folate and vitamin B(12) deficiency may reflect a common abnormality of metabolism.

Minimal criteria for the diagnosis of megaloblastic anaemia of pregnancy.

The routine examination of buffy coat films is a valuable diagnostic aid to screening large numbers of specimens of blood and is applicable to hospital and general practice, provided that a bottle of sequestrinated venous blood can be examined in the laboratory within 24 hours.The diagnosis of folic-acid deficiency anaemia of pregnancy can be made, in many cases, before the appearance of megalo...